More cases of swine flu were confirmed Monday in the United States, Canada and Europe as the World Health Organization described the outbreak as a "public health emergency of international concern."
Relatives of flu patients wait oustside Mexico's National Institute of Respiratory Diseases.
It said the U.S. has confirmed 40 cases, Mexico 26, Canada six and Spain one. Two more were confirmed in Scotland.
In Mexico the virus is believed to be responsible for at least 149 deaths -- though most of those have not yet been confirmed -- while almost 2,000 have been hospitalized.
Some health experts fear the disease could become a pandemic, partly because it has killed young, healthy adults in Mexico.
Health Secretary Jose Angel Cordoba Villalobos said. "The number of cases, unfortunately, will continue to increase," he said.
Mexico closed all schools until at least May 6 to help curb the spread of swine flu, officials announced Monday.
A U.S. federal official confirmed the U.S. figure -- up from 20 with all the new cases coming from a New York school where eight cases were previously confirmed.
The European Union's health commissioner Monday called on people to avoid traveling to both Mexico and the United States. 
Watch how the disease is emptying churches and soccer grounds »
People "should avoid traveling to Mexico or the U.S. unless it is very urgent for them," Andorra Vassiliou said.
The first case of swine flu in Europe was confirmed Monday in Spain. Health minister Trinidad Jimenez said a 23-year-old man who returned from studying in Mexico last Wednesday tested positive for the virus at a hospital in southeastern Spain.
At least 16 more cases are being treated as possible swine flu, Jimenez told a news conference. Earlier, Jimenez met with health officials to discuss Spain's response to the crisis.
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"We do not have an emergency situation in Spain, but we are working to prevent any possible development, and we are taking action in accord with the World Health Organization," she said.
Spain's Ministry of Health has urged travelers recently returned from Mexico and the U.S. to be on the lookout for symptoms of the virus, including fever, coughing and respiratory problems.
A few hours later, Scottish Health Secretary Nicola Sturgeon said: "Tests have demonstrated conclusively that the two Scottish cases of swine flu are positive."
U.N. Secretary-General Ban Ki-Moon said: "We are concerned that this virus could cause a new influenza pandemic. It could be mild, in its effects, or potentially be severe. We do not yet know which way it will go. But we are concerned that, in Mexico, most of those who died were young and healthy adults.
Dr. Richard Besser, acting director of the Centers for Disease Control and Prevention in Atlanta, Georgia, said the EU warning was "not warranted." Watch the CDC assessment »
President Barack Obama said Monday that the outbreak was a "cause for concern" but not a "cause for alarm."
He said the federal government was "closely monitoring" emerging cases and had declared a public health emergency as a "precautionary tool" to ensure the availability of adequate resources to combat the spread of the virus.
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Israel and New Zealand, where 22 students and three teachers were quarantined after returning for a three-week trip to Mexico, are also investigating suspected cases. South Korea says it will test travelers arriving from the U.S.
Swine flu is a contagious respiratory disease that usually affects pigs. It is caused by a type-A influenza virus. The current strain is a new variation of an H1N1 virus, which is a mix of human and animal versions.
When the flu spreads person-to-person, instead of from animals to humans, it can continue to mutate, making it harder to treat or fight off because people have no natural immunity.
The symptoms are similar to common flu. They include fever, lethargy, lack of appetite, coughing, runny nose, sore throat, nausea, vomiting and diarrhea.
The virus spreads when an infected person coughs or sneezes around another person. People can become infected by touching something with the flu virus on it and then touching their mouth, nose or eyes.
Researchers are trying to determine how easily it can jump from person to person. Keiji Fukuda, WHO's assistant director-general, said it was too early to predict whether there will be a mild or serious pandemic. iReport.com: Do you think we should be worried about swine flu?
In 1968, a "Hong Kong" flu pandemic killed about 1 million people worldwide. And in 1918, a "Spanish" flu pandemic killed as many as 100 million people.
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